What antidepressants are sold. Antidepressants without prescriptions - names of new generation drugs, main characteristics, recommendations for use. Treatment with antidepressants - consequences

Update: October 2018

Depression can be described as general emotional exhaustion. As a rule, this is due to the inability to solve an important, from the point of view of this person, task. When a person is suppressed by external circumstances and fails to adequately realize their desires and ambitions, the body may well respond with situational depression.

Another common type of depressive disorder is somatic depression. At the same time, mental discomfort results in diseases of internal organs (peptic ulcer, hormonal disorders, cardiovascular problems).

Depressions are also known against the background of fluctuations in the level of sex hormones (during menopause or after childbirth), as a result of prolonged stress, chronic or incurable illness, injury or disability.

In general, depression is irritability multiplied by weakness against the background of a low level of your own pleasure hormones (enkephalins and endorphins) in the brain, which leads to dissatisfaction with yourself and the surrounding reality in the absence of the strength to radically change anything.

Possible workarounds are support from the environment, a specialist (psychiatrist or psychologist) and / or medication. With a favorable set of circumstances, this will help to choose new priorities in life and get rid of the very reason that entailed a painful state of mind.

Medicines used to treat depression are called antidepressants. Their use has made a splash in psychiatry and has significantly improved the prognosis of patients with depression, as well as significantly reduced the number of suicides on the background of depressive disorders.

Antidepressants without a prescription

Today, only the lazy do not deal with depression. Psychologists with pedagogical education, coaches of all stripes, traditional healers and even hereditary sorceresses. All this heterogeneous company nevertheless reads something on the problem and understands that it is unlikely that it will be possible to cure a real clinically pronounced depression simply by talking and laying on hands.

Yes, and many who feel that they have begun to fall into a pit of a depressive state, but are afraid to contact a psychiatrist, do not mind taking drugs that could simply be bought without a prescription at a pharmacy. This is because the system of psychiatric care in our country is still more like a light mixture of the army and the bazaar, because either immediately “registered” or for money!

Let's immediately disappoint the audience with the message that antidepressants today are prescription drugs. If in some commercial pharmacy, in violation of the rules, they sell something without a prescription, then antidepressants do not become OTC from this. They have a lot of serious side effects, so the advisability of taking them, individual selection of dosages should be carried out only by the attending physician.

Unfortunately, simply taking some kind of antidepressant and hoping for a quick release from depression is a hopeless business. After all, there are different types of depression. On the same dosages of the same depression medication, one patient achieves a complete clinical recovery, while another is just beginning to develop suicidal thoughts.

What are the best antidepressants to take

Any sane person understands that it is better to be treated with those drugs that are prescribed by a specialist who understands this, is guided by the standards of treatment, information about the drug and his clinical experience in using the drug.

Turning your own precious body into a testing ground for antidepressants is, at the very least, imprudent. If such a fixed idea has already been visited, then it is better to find some Institute of Psychiatry, where programs for the clinical testing of medicines are regularly held (at least you will receive competent advice and free treatment).

In general, antidepressants are drugs that elevate mood, improve overall mental well-being and also cause emotional uplift without falling into euphoria or ecstasy.

Names of antidepressants

Antidepressants can be divided depending on the effect on the processes of inhibition. There are drugs with a calming, stimulating and balanced effect.

• Calming: Amitriptyline, Pipofezin (Azaphen), Mianserin (Lerivon), Doxepin.
• Stimulants: Metralindol (Inkazan), Imipramine (Melipramine), Nortriptyline, Bupropion (Wellbutrin), Moclobemide (Aurorix), Fluoxetine (Prozac, Prodel, Profluzak, Fluval).
• Balanced drugs: Clomipramine (Anafranil), Maprotiline (Ludiomil), Tianeptine (Coaxil), Pyrazidol.

All of them are divided into seven large groups, each of which has its own indications and preferences for certain manifestations of depression.

Tricyclic antidepressants

These are first generation drugs. They interfere with the reuptake of norepinephrine and serotonin in the nerve synapse. Due to this, these mediators accumulate in the nerve junction and accelerate the transmission of the nerve impulse. These funds include:

• Amitriptyline, Doxepin, Imipramine
• Desipramine, Trimipramine, Nortriptyline

Due to the fact that this group of drugs has quite a lot of side effects (dry mouth and mucous membranes, constipation, difficulty urinating, heart rhythm disturbances, hand tremors, visual impairment), they are used less and less.

Selective serotonin reuptake inhibitors

• Sertraline - Aleval, Asentra, Zoloft, Seralin, Stimuloton
• Paroxetine - Paxil, Reksetin, Adepress, Pleasil, Actaparoxetine
• Fluoxetine - Prozac, Fluval, Prodel
• Fluvoxamine - Fevarin
• Citalopram - Oprah, Cipralex, Selectra

Such antidepressants are preferred for neurotic depression, accompanied by fears, aggression,. The side effects of these drugs are not extensive. The main one is nervous excitement. But large doses or an overdose can lead to the accumulation of serotonin and serotonin syndrome.

This syndrome is manifested by dizziness, trembling of the limbs, which can develop into convulsions, increased blood pressure, nausea, diarrhea, increased motor activity, and even mental disorders.

That is why popular and good antidepressants like fluoxetine (Prozac), which enterprising pharmacists sometimes sell without a prescription, if taken uncontrollably or in excess of doses, can bring a person from banal mood disorders to a convulsive seizure with loss of consciousness, a hypertensive crisis or cerebral hemorrhage, or even all the way to the “moving roof”.

Selective serotonin and norepinephrine reuptake inhibitors

They work similarly to the drugs of the previous group. Milnacipran and venlafaxine are indicated for depression with obsessive-compulsive disorder or phobias. Of the side effects, they are characterized by headache, drowsiness, anxiety.

Heterocyclic antidepressants

Heterocyclic antidepressants (with receptor action) are preferred in the elderly and in combinations of depression with sleep disorders. Cause drowsiness, may increase appetite and contribute to weight gain.

• Mianserin (Lerivon), Nefazodon
• Mirtazapine (Remeron), Trazodone (Trittico)

Monoamine oxidase inhibitors

Drugs of choice for depressive disorders with panic attacks, fear of open spaces, with psychosomatic manifestations (when depression provokes internal diseases). They are divided into:

• irreversible - Tranylcypromine, Phenelzine
• reversible - Befol, Pyrazidol (Normazidol), Moclobemide (Aurorix)

Serotonin reuptake activators - new generation antidepressants

Able to cope with the symptoms of depression in one week. They are effective in somatized depression with palpitations, headaches. They are also used for depression of an alcoholic nature or depression with psychosis against the background of cerebrovascular accidents. But these drugs can be addictive like opiates, these include: Tianeptine (Coaxil).

These powerful over-the-counter antidepressants were no longer sold after several years across the post-Soviet space many lovers of inexpensive highs misused them. The result of such experiments was not only multiple inflammation and thrombosis of the veins, but also a shortening of life up to 4 months from the start of systematic use.

Antidepressants of different groups

• Buspirone (Spitomin), Nefazadone
• Heptral (see)
• Bupropion (Wellbutrin)

List of new generation antidepressants

The most popular today are drugs from the group of selective serotonin and norepinephrine reuptake blockers.

• Sertraline(Serlift, Zoloft, Stimuloton) is the "gold standard" in the treatment of depression today. It is compared with other drugs in terms of effectiveness. It is preferred in the treatment of depression associated with overeating, obsessions and anxiety.
• Venlafaxine(Venlaxor, Velaksin, Efevelon) - prescribed for depression against the background of more severe mental disorders (for example, schizophrenia).
• Paroxetine(Paxil, Reksetin, Adepress, Cyrestill, Pleasil) - effective for mood disorders, melancholy and inhibited depression. Also removes anxiety, suicidal tendencies. Treats personality disorders.
• Opipramol- the best option for somatized and alcoholic depression, as it inhibits vomiting, prevents convulsions, stabilizes the autonomic nervous system.
• Light antidepressants are fluoxetine (Prozac), which are somewhat weaker but milder than other serotonin reuptake inhibitors.

Antidepressants and tranquilizers: difference between groups

In addition to antidepressants, tranquilizers are also used in the treatment of depression:

• This group of medicines eliminates the feeling of fear, emotional stress and anxiety.
• At the same time, drugs do not violate memory and thinking.
• Additionally, tranquilizers are able to prevent and remove convulsions, relax muscles, and normalize the functioning of the autonomic nervous system.
• In medium doses, tranquilizers lower blood pressure, normalize heart rate and blood circulation in the brain.

Thus, tranquilizers differ from antidepressants mainly by the opposite effect on the autonomic nervous system. Also, tranquilizers have the greatest effect on fear and anxiety, which can be removed even with a single dose, and antidepressants require a course of treatment. Tranquilizers are more likely to cause dependence and their withdrawal syndrome is more pronounced and severe.

The main side effect of the group is addiction. Also, drowsiness, muscle weakness, lengthening of reaction time, unsteady gait, speech disorders, urinary incontinence, weakening of sexual desire may also develop. In case of an overdose, paralysis of the respiratory center and respiratory arrest may develop.

With the abrupt cancellation of tranquilizers after their long-term use, a withdrawal syndrome may develop, manifested by sweating, trembling of the extremities, dizziness, sleep disturbances, intestinal dysfunctions, headache, drowsiness, increased sensitivity to sounds and smells, tinnitus, reality perception disorders, depression.

An Overview of Herbal Antidepressants (Over the Counter)

Often, antidepressants include herbal sedatives, which are not any antidepressants:

• Preparations of Valerian, Melissa, Peppermint, Motherwort
• Combined tablets - Novopassit, Persen, Tenoten - These are sedatives that will not help with depression.

The only medicinal plant with antidepressant properties is perforated and preparations based on it, which are prescribed for mild depressive states.

There is one thing: to eliminate the manifestations of depression, synthetic drugs that are ten times more effective than St. John's wort, you have to drink courses for several months. Therefore, St. John's wort will have to be brewed, insisted in kilograms, and consumed in liters, which, of course, is inconvenient, and inappropriate, although it can somewhat distract from sad thoughts about the frailty of everything during depression.

The pharmacological industry offers St. John's wort perforated in tablet form without a prescription as a mild antidepressant (nootropic) for psychovegetative disorders, neurotic reactions, mild depressive states - these are Deprim, Neuroplant, Doppelherz nervotonik, Negrustin, Gelarium. Since the active substance in the preparations is the same, contraindications, side effects, interaction with other drugs of these drugs are similar.

Deprim Ingredients: dry standardized extract of St. John's wort. It has a pronounced sedative effect, since the active substances of St. John's wort - pseudohypericin, hypericin, hyperforin and flavonoids have a positive effect on the functional state of the central nervous system and the autonomic nervous system. Increases physical activity, improves mood, normalizes sleep. Indications: sensitivity to weather changes, mild depression, anxiety, Contraindications: severe depression, pills are contraindicated for children under 6 years old, capsules up to 12 years old, hypersensitivity - allergic reactions to St. Dosage: from 6 to 12 years only under the supervision of a physician, 1-2 tablets in the morning and evening, for adults, 1 capsule or tablet 1 r / day or 3 r / day, possibly 2 tablets 2 times a day. The effect occurs after 2 weeks of taking, you can not take a double dose in case of missing a dose. Side effects: constipation, nausea, vomiting, anxiety, fatigue, pruritus, skin redness, photosensitivity - simultaneous use of the drug and sunbathing can lead to (see). Tetracyclines, thiazide diuretics, sulfonamides, quinolones, piroxicam especially increase photosensitivity. Overdose: weakness, drowsiness, side effects increase. Special instructions: the drug should be carefully prescribed simultaneously with other antidepressants, oral contraceptives (see), it is not prescribed simultaneously with cardiac glycosides, cyclosporine, theophylline, indinavir, reserpine. Enhances the effect of analgesics, general anesthesia. Alcohol, sun exposure and other UV exposure should be avoided while taking. If after a month of taking there is no improvement, the reception is stopped and you should consult a doctor.

Neuroplant 20 tab. 200 rub. Ingredients: dry extract of St. John's wort, ascorbic acid. Indications and contraindications similar to the drug Deprim. In addition, Neuroplan is strictly contraindicated for children under 12 years of age, for women during pregnancy and lactation, with increased photosensitivity, it is prescribed with caution in diabetes mellitus. Dosage: It is better to take before meals, do not chew, but take 1 tablet whole with water. 2-3 r / day, also if there is no effect for several weeks of administration, the drug is canceled and the treatment is adjusted. Side effects: indigestion, skin allergic reactions, psycho-emotional stress, apathy,. Concomitant use with other drugs: reduces the concentration of hormonal contraceptives and increases the risk of . When taken simultaneously with antidepressants, the likelihood of side effects increases - unreasonable fear, anxiety, vomiting, nausea, as well as a decrease in the effect of amitriptyline, midazolam, nortriptyline. When taken with drugs that increase photosensitivity, the risk of photosensitivity increases. Neuroplant reduces the therapeutic effect of indinavir and other HIV protease inhibitors, drugs used to treat cancer that inhibit cell growth.

Doppelhertz nervotonic 250 ml. 320-350 rub. Ingredients: Elixir Doppelherz Nervotonik - liquid extract of St. John's wort, as well as cherry liqueur concentrate and liqueur wine. Indications and contraindications Deprim and Neuroplant are similar. Additionally: with caution, Doppelgerz Nervotonik is taken for diseases of the brain, for liver diseases, craniocerebral injuries, and for alcoholism. Side effects: rarely allergic reactions, in persons with fair skin with a tendency to photosensitivity - photosensitivity reactions. Application: 3 r / day, 20 ml. after eating for 1.5 -2 months, if there is no effect, you should consult a doctor. Special instructions: as with other drugs with St. John's wort extract, interactions with other drugs should be taken into account when taken simultaneously. The drug contains 18 vol.% ethanol, that is, when taking the recommended dose, 2.8 g of ethanol enters the body, so you should refrain from driving vehicles and working with other mechanisms that require the speed of psychomotor reactions (driving a car, working as a dispatcher, working with moving mechanisms etc.)

Negrustin Capsules Negrustin - dry extract of St. John's wort Solution Negrustin - liquid extract of St. John's wort Indications, contraindications and side effects similar to other preparations of St. John's wort. Dosage: children over 12 years old and adults 1 capsule 1-2 r / day or 3 r / day, 1 ml. solution, the course of therapy is 6-8 weeks, possibly repeated courses. Capsules can be taken with meals, washed down with liquid, the solution can also be taken diluted with meals, or not diluted. Special instructions: As with other drugs with the active ingredient of St. John's wort extract, care should be taken when combined with the drugs listed above. Negrustin's solution contains sorbitol and 121 mg of it is supplied at each dose. Also, the drug is prescribed with caution to persons with fructose intolerance. Negrustin, with the simultaneous use of alcohol or tranquilizers, affects the psychophysical abilities of a person (driving vehicles and working with other mechanisms).

Gelarium Dragee Gelarium Hypericum is a dry extract of St. John's wort herb. Indications, contraindications, side effects, interaction with other drugs similar to all drugs with St. John's wort. Application: 1 tablet 3 r / day over 12 years and adults, a course of at least 4 weeks, during a meal, drinking water. Special instructions: the interval between taking the above drugs (when taken simultaneously) should be at least 2 weeks; in case of diabetes, it should be borne in mind that a single dose contains less than 0.03 XE.

In pharmacy chains, phytopreparations with St. John's wort are widely represented, the price is 20 filter bags or 50 gr. dry matter 40-50 rubles.

Depression affects not only adults but also children. This disease has been studied more than once, but is still not fully understood. Literally, the concept of "depression" means the loss of vital energy. Symptoms of depression are bad mood, lethargy, gloom, unwillingness to do anything, loss of activity.

Depression is characterized by a loss of interest in life, therefore, it does not imply the manifestation of active methods for correcting this condition. According to many experts, in this case, sports and involvement in an active lifestyle are an effective way of treatment. But a person with depression does not have enough strength to force himself to be active in any degree. Therefore, often, the only way to get rid of an oppressed state and add strength and energy are drugs called.

This antidepressant first appeared in 1974 in the United States. Currently, it is widely known in Europe under the name "Prozac". In our country, this drug is widely and successfully used to treat depression and related conditions.

Of all the drugs in this group, Paroxetine is the most powerful. It effectively corrects anxiety and depression. There are many medicines based on paroxetine: Adepress, Plizil, Veropharm, Reksetin and others.

Regardless of the names and manufacturer, Paroxetine has positive reviews from both doctors and patients. This medicine has other names: "Veltrubin", "Zyban", "NowSmok". The active substance of these drugs is bupropion hydrochloride, which increases the amount of dopamine and norepinephrine in the brain. These medications are also effective in quitting smoking to alleviate addiction symptoms.

Quite popular is Simbalta, a fourth-generation drug whose action is based on the capture of dopamine. The active substance of this drug is duloxetine. This substance is characterized by high efficiency and speed of action. A lasting effect is achieved by the end of the first week of taking the drug.

Despite the mass of positive reviews, there are a number of patients who do not have high reviews. It's all about individual differences.

Some drugs are no longer easy to find in pharmacies. Especially second-generation antidepressants, which have the most severe side effects. Antidepressants are available only under the supervision of psychiatrists. The choice of drug depends on the price category, the depth of depression and the presence of interactions with other drugs. The latter is especially dangerous, as it can produce an unpredictable effect.

When taking antidepressants, be aware of the inadmissibility of taking alcoholic beverages. It is extremely dangerous for mental and physical health. The reason for this is that both alcohol and antidepressants have a very strong effect on the central nervous system.

You should not think about which drug is better. If each new day is harder for you than the previous one, then you should immediately consult a doctor. Modern medicine offers not only drugs, but a whole arsenal of effective means: acupuncture, breathing exercises, physiotherapy, baths and massages. But the main thing is your desire to be a happy person.

Effective modern dual-acting antidepressants are spared some of the side effects of previous analogues. Their use gives a positive result in 2-3 weeks. Due to the various side effects of the group of antidepressants, it is difficult to choose one effective remedy. Consider the most popular new antidepressants that are prescribed in our country. Let's compare them with analogues used in Europe.

New antidepressants of the new generation SNRIs group are prescribed for depressive states. The effectiveness of their use depends on the strength and proportionality in the selective inhibition of norepinephrine and serotonin receptors. The ability to block the release of both substances eliminates the need to use several drugs in pathologies with impaired metabolism of both mediators. The most popular antidepressants in Russia are fluoxetine, venlafaxine, milnacipral, deloxetine.

Attention! Drugs are sold in pharmacies only by prescription.

Venlafaxine

A fairly strong drug with a narcotic side effect that occurs due to a pronounced blockade of norepinephrine release in nerve synapses. It is prescribed for schizophrenia and other mental disorders accompanied by depressive conditions.

Fluoxetine (Portal)

For milder depressive disorders, it is better to replace venlafaxine with fluoxetine. Its effect is associated with a decrease in the uptake of serotonin, which forms a "softer" action. The drug is used worldwide for depressive disorders, bulimia nervosa, but other new generation antidepressants are preferable to it.

The drug was widely used due to the lack of effect on the metabolism of other mediators, except for norepinephrine and serotonin. The stimulating and weak sedative activity of fluoxetine made it possible to use it in the outpatient clinical practice of a doctor.

Regardless of the time of administration, the medicine is well absorbed. Its half-life is 1-3 days. The duration of action up to 15 days, which is described in the annotation to the drug, is determined by its active metabolite, norfluxetine. Fluoxetine is produced under the name "portal" by the company "LEK". 20 mg of fluoxetine contains a capsule "portal". The standard dose of an antidepressant for fears and phobias is 1 capsule per day.

Clinical studies have shown that the "portal" is particularly effective in the treatment of depression of various origins. Modern antidepressants such as "portal" are used to treat patients with compulsive-obsessional disorders in old age.

"Portal" is well tolerated by patients. Side effects are either mild or absent. In any case, if negative effects are detected when using the drug, it should not be canceled, but only corrective therapy of disorders should be carried out. A contraindication to the appointment is hypersensitivity to MAOIs and fluoxetine.

Sertraline

A new generation antidepressant with the most pronounced effect. It is the "gold standard" in the treatment of anxiety and depression. Maximum effectiveness is observed in bulimia nervosa (lack of appetite). Dose - 50-200 mg per day.

Paxil

It has anxiolytic and thymoanaleptic effects. It is used for inhibited and dreary depressions, relieves suicidal thoughts and treats personality disorders. Anxiety quickly disappears with a daily dose of 10-40 mg. In some cases, doctors increase the dosage to 80 mg.

Insidon (opipramol)

Antidepressant with antiemetic, hypothermic and anticonvulsant effects. Antiserotonin, analgesic and antihistamine activity is manifested. Insidon is used to stabilize the active background. In the first days of using the drug, a pronounced tranquilizing effect can be traced.

Additionally, opipramol is used to stabilize the autonomic system with dyskinesias of the urogenital organs, intestines, heart pain, vegetative-vascular dystonia (VVD). Due to the above effects, antidepressants of the opipramol group are considered "psychosomatic hormones".

They are used at the outpatient stage and in hospitals for myocardial infarction, treatment of diseases of internal organs, bronchial asthma, angina pectoris, and increased pressure. The therapeutic dose is 100-200 mg per day.

Clinical trials of new generation antidepressants

Antidepressants of the new generation have proven themselves well in clinical trials that were conducted in Holland. When determining the effectiveness of drugs in vitro to assess their positive and negative sides, it is necessary to exclude the "placebo" effect. It refers to a psychological state of improvement that is not justified by the biochemical action of the drug.

Sertraline is the "gold standard" against which other antidepressants are compared.

Clinical studies in Holland have revealed some interesting features of modern drugs for the treatment of depression. So in 42 independent studies, the superiority in therapeutic effect was confirmed:

• citalopram over reboxetine,
• fluoxetine over,
• reboxetine over paroxetine,
• Escitalopram on citalopram
• Mirtazopine on fluoxetine,
• Sertraline over fluoxetine.

In terms of tolerance, fluoxetine is noticeably distinguished, which acts “softly”, but its therapeutic effect is weaker than that of other analogues.

Group combination therapy is more effective than mirtazapine, escitalopram, venflaxin, and sertraline over fluvoscamine, fluoxetine, and duloxetine. When using sertraline alone, the therapeutic effect is slightly lower than with combination therapy with vanlafaxine, mirtazapine and escitalopram.

Some modern antidepressants of the new generation have a pronounced effect on the exchange of serotonin and norepinephrine in nerve cells. This mechanism of action allows them to be used in the treatment of chronic forms of the disease.

For example, venlafaxine (effexor) is a selective serotonin receptor blocker, but with increasing dosage blocks the reuptake of norepinephrine.

Remeron (Mirtazapine) is a tetracyclic antidepressant with a specific mechanism of action. It increases the level of histamine, affecting the postsynaptic level of serotonin metabolism. The drug is prescribed at bedtime for insomnia. This approach is explained by an increase in the concentration of histamine, which leads to drowsiness. However, mirtazapine also increases the level of noradrenaline, therefore, in addition to the calming effect, it has side effects, like other antidepressants.

The Ukrainian antidepressant of the latest generation "Miaser" is actively discussed in the press. The manufacturer claims that it does not form addiction, but in clinical practice there is a state of drowsiness, unsteady gait in patients to whom it is prescribed for 2 weeks.

The results of Dutch studies confirmed that reboxetine exhibits the weakest effect of all the antidepressants discussed above.

The experiments were carried out in a sample of 66 people in the treatment of depressive conditions. The drug is not registered in the Netherlands, as it shows minimal efficacy in the treatment of mental disorders.

The latest generation antidepressants prescribed in Russia (paroxetine and fluosetine) are not on the list of first choice drugs in European countries.

Nodepress is rightfully considered one of the best remedies when high-efficiency antidepressants are required. It meets all international requirements that apply to this group of drugs. Nodepress has a wide range of applications. It does not have a sedative effect, does not cause drowsiness and lethargy. The drug is not addictive. Let's combine with other medicines.

Valdoxan is used primarily to normalize sleep. Its active ingredient, agomelatine, accelerates the release of dopamine in the prefrontal cortex of the brain, but does not affect serotonin levels. Agomelatine restores the normal structure of sleep, and also reduces the temperature caused by the instability of neurological processes.

These drugs and antipsychotics for depression can be used in the case of relief of affective-delusional syndromes in children and adults.

The most common mild antidepressants are:

This is only some of the antidepressants used to combat nervous disorders and depression. All of them are divided into several classifications.

soothing

Calming antidepressants - a classification of the most common drugs to combat depression.

Amitriptyline belongs to the classical type of mild tricyclic antidepressants. It is distinguished from Imipramine by a rather strong sedative effect. It is used to get rid of depressions of anxious and agitated types, which can manifest themselves with "vitality". This drug is available in the form of tablets and injections.

Another domestic antidepressant is Azafen, or Hypophysin. It is used to combat the symptoms of "minor" depressive disorders of the cyclothymic register. The drug has moderate sedative and thymoanaleptic effects.

Mianserin, or Lerivon, is a drug that, when used in small doses, has a strong sedative effect. Due to this effect, it can be used to treat cyclothymia in combination with insomnia. It is able to cure depression with large episodes.

Stimulants

Moclobemide, or Aurorix, is a selective MAO inhibitor. The drug has a powerful stimulating effect on people suffering from inhibited types of depression. It is prescribed for somatized types of depression. But the drug is strictly prohibited for use in anxiety depression.

Imipramine, or Melipramine, is the first fully studied tricyclic antidepressant. It is used in the treatment of severe depression with a high predominance of sadness and lethargy, with suicidal thoughts. The drug is produced both in the form of tablets and in the form of intramuscular injections.

Fluoxetine is a thymoanaleptic drug. Its second name is Prozac. The drug is effective in the treatment of depression with obsessive-phobic symptoms.

This type of drug belongs to the so-called selective serotonin reuptake inhibitors (SSRIs). The drug is devoid of some of the effects of clinical tricyclic antidepressants:

• antihistamine;
• adrenolytic;
• anticholinergic.

Pertofran is a more powerful version of Imipramine (desmethylated). It has a brighter activating effect. The drug is used to combat depression, combined with depersonalization.

Preparations of a balanced effect

The second name of Pyrazidol is Pirlindol. The drug is produced in Russia. It is a reversible MAO type A inhibitor, like Moclobemide. This drug is used to prevent and treat depression of the inhibited type, as well as depressive disorders with pronounced anxiety manifestations. The advantages of the drug in the possibility of taking it for glaucoma, prostatitis and cardiac pathologies.

Another powerful drug created as a result of the synthesis and introduction of a chlorine atom into the imipramine molecule is Anafranil. It is used for the treatment of resistant-type depression and for the relief of the affective phases of severe depression.

Maprotiline, or Lyudiomil, is a tetracyclic antidepressant. It has a fairly powerful thymoanaleptic effect when interacting with anxiolytic and sedative components. It can be used in circular depression in combination with ideas of self-blame. The drug is used for involutional melancholia. Maprotiline is produced in the form of oral preparations and injections.

Reversible monoamine oxidase inhibitors and selective reuptake inhibitors

Befol refers to domestic drugs that are prescribed for depressive disorders of asthenic and anergic types. It is used to treat the depressive phase of cyclothymia.

Fevarin and Fluoxetine belong to the classification of thymoanaleptic drugs. The preparations have a vegetative-stabilizing effect.

Citalopram and Cipramil are other names for thymoanaleptic antidepressants that can be used to treat depression. They belong to the group of sedative serotonin reuptake inhibitors (SSRIs).

Afobazole is an over-the-counter antidepressant. It is used to combat somatic diseases with adjustment disorders, anxiety, neurasthenia, and oncological and dermatological diseases.

The drug has a good effect in the treatment of sleep disorders and the removal of symptoms of PMS. But it should be borne in mind that taking it to children and women during pregnancy and lactation is contraindicated.

Tricyclic

Trimipramine, or Gerfonal, is used in the treatment of depression with increased anxiety. This is one of the most powerful drugs of its kind. Its psychotropic activity is similar to Amitriptyline. When conducting treatment, it is worth considering the list of contraindications for this antidepressant:

• dry mouth;
• orthostatic hypotension;
• problems with urination.

Sertraline and Zoloft are the names of antidepressants with a strong thymoanaleptic effect with a weak stimulating effect. At the same time, the drugs do not have anticholinergic and cardiotoxic properties.

They achieve the maximum effect in the fight against somatized atypical depressions with some manifestations of bulimia.

Paroxetine is a derivative of piperidine. It has a fairly complex bicyclic structure. The main properties of Paroxetine are thymoanaleptic and anxiolytic. They appear in the presence of stimulation.

The drug shows itself well in the fight against endogenous and neurotic depressions, their dreary or inhibited variants.

Venlafaxine is an antidepressant used for depression associated with severe mental disorders such as schizophrenia, etc.

Opipramol is used to treat somatic and alcoholic depression. It is able to prevent vomiting, convulsions and generally stabilize the autonomic nervous system.

Toloxatone, or Humoril, is similar in how it affects the human body with Moclobemide. The drug has no anticholinergic and cardiotoxic properties. But he copes well with the treatment of depression with pronounced lethargy.

Cymbalta or Duloxetine are used to fight depression with panic attacks.

Side effects

Most antidepressants have their fair share of side effects. Their list is quite large:

• hypotension;
• arrhythmia;
• sinus tachycardia;
• violation of intracardiac conduction;
• oppression of bone marrow functions;
• agranulocytosis;
• thrombocytopenia;
• hemolytic anemia;
• dry mucous membranes;
• disturbance of accommodation;
• intestinal hypotension;
• problems with urination;
• increased appetite;
• weight gain.

Such side effects due to the use of the tricyclic type of antidepressants occur quite often. In contrast, serotonin reuptake inhibitor antidepressants have less side effects. But these may be:

• frequent headaches;
• insomnia;
• anxiety states;
• depotent effects.

If combination therapy is used for treatment, that is, drugs of both types are used simultaneously, then serotonin syndrome may occur, characterized by fever, signs of intoxication of the body and disorders in the work of the heart and blood vessels.

Any antidepressants for depression should be taken only after a complete medical examination and an accurate and complete diagnosis.

And for children, they are prescribed with extreme caution. Be sure to do this under the supervision of a doctor so as not to harm the body.

All about modern antidepressants: a list of the top 30 drugs at the end of 2017

Antidepressants are drugs that are active against depression. Depression is a mental disorder characterized by a decrease in mood, a weakening of motor activity, intellectual scarcity, an erroneous assessment of one's "I" in the surrounding reality, and somatovegetative disorders.

The most likely cause of depression is a biochemical theory, according to which there is a decrease in the level of neurotransmitters - biogenic substances in the brain, as well as a reduced sensitivity of receptors to these substances.

All drugs in this group are divided into several classes, but now - about history.

History of the discovery of antidepressants

Since ancient times, mankind has approached the issue of treating depression with different theories and hypotheses. Ancient Rome was famous for its ancient Greek physician named Soranus of Ephesus, who offered lithium salts for the treatment of mental disorders, including depression.

In the course of scientific and medical progress, some scientists have resorted to a range of substances that have been used against the war on depression - from cannabis, opium and barbiturates, to amphetamines. The last of them, however, was used in the treatment of apathetic and sluggish depressions, which were accompanied by stupor and refusal of food.

The first antidepressant was synthesized in the laboratories of the Geigy company in 1948. This drug was Imipramine. After that, they conducted clinical studies, but did not begin to release it until 1954, when Aminazine was obtained. Since then, many antidepressants have been discovered, the classification of which we will discuss later.

Magic pills - their groups

All antidepressants are divided into 2 large groups:

1. Thymiretics are drugs with a stimulating effect that are used to treat depressive conditions with signs of depression and oppression.
2. Thymoleptics are drugs with sedative properties. Treatment of depressions with predominantly excitatory processes.

• block the capture of serotonin - Flunisan, Sertraline, Fluvoxamine;
• block the uptake of norepinephrine - Mapotelin, Reboxetine.

• non-selective (inhibit monoamine oxidase A and B) - Transamine;
• selective (inhibit monoamine oxidase A) - Autoriks.

Antidepressants of other pharmacological groups - Coaxil, Mirtazapine.

Mechanism of action of antidepressants

In short, antidepressants can correct some of the processes that occur in the brain. The human brain is made up of a huge number of nerve cells called neurons. A neuron consists of a body (soma) and processes - axons and dendrites. The connection of neurons with each other is carried out through these processes.

It should be clarified that they communicate with each other by a synapse (synaptic cleft), which is located between them. Information from one neuron to another is transmitted with the help of a biochemical substance - a mediator. Currently, about 30 different mediators are known, but the following triad is associated with depression: serotonin, norepinephrine, dopamine. By regulating their concentration, antidepressants correct the impaired brain function due to depression.

The mechanism of action differs depending on the group of antidepressants:

1. Neuronal uptake inhibitors (non-selective action) block the reuptake of mediators - serotonin and norepinephrine.
2. Serotonin neuronal reuptake inhibitors: They inhibit the reuptake of serotonin by increasing its concentration in the synaptic cleft. A distinctive feature of this group is the absence of m-anticholinergic activity. Only a slight effect on α-adrenergic receptors is exerted. For this reason, such antidepressants are virtually free of side effects.
3. Norepinephrine reuptake inhibitors: prevent the reuptake of norepinephrine.
4. Monoamine oxidase inhibitors: Monoamine oxidase is an enzyme that destroys the structure of neurotransmitters, as a result of which they are inactivated. Monoamine oxidase exists in two forms: MAO-A and MAO-B. MAO-A acts on serotonin and norepinephrine, MAO-B - dopamine. MAO inhibitors block the action of this enzyme, thereby increasing the concentration of mediators. As drugs of choice in the treatment of depression, MAO-A inhibitors are more often stopped.

Modern classification of antidepressants

The tricyclic group of drugs produces a blocking of the transport system of presynaptic endings. Based on this, such agents provide a violation of the neuronal uptake of neurotransmitters. This effect allows a longer stay of these mediators in the synapse, thereby providing a longer effect of mediators on postsynaptic receptors.

The drugs of this group have α-adrenoblocking and m-anticholinergic activity - they cause such side effects:

• dryness in the mouth;
• violation of the accommodative function of the eye;
• atony of the bladder;
• lowering blood pressure.

Scope of application

It is rational to use antidepressants for the prevention and treatment of depression, neurosis, panic conditions, enuresis, obsessive-compulsive disorder, chronic pain syndrome, schizoaffective disorder, dysthymia, generalized anxiety disorder, sleep disorder.

There are data on the effective use of antidepressants as an auxiliary pharmacotherapy for early ejaculation, bulimia and smoking.

Side effects

Since these antidepressants have a variety of chemical structures and mechanisms of action, side effects may vary. But all antidepressants have the following common symptoms when they are taken: hallucinations, agitation, insomnia, the development of a manic syndrome.

Thymoleptics cause psychomotor retardation, drowsiness and lethargy, decreased concentration. Thymiretics can lead to psychoproductive symptoms (psychosis) and increased anxiety.

The most common side effects of tricyclic antidepressants include:

• constipation;
• mydriasis;
• urinary retention;
• intestinal atony;
• violation of the act of swallowing;
• tachycardia;
• impaired cognitive functions (impaired memory and learning processes).

Elderly patients may experience delirium - confusion, disorientation, anxiety, visual hallucinations. In addition, the risk of weight gain, the development of orthostatic hypotension, and neurological disorders (tremor, ataxia, dysarthria, myoclonic muscle twitching, extrapyramidal disorders) increase.

With prolonged use - cardiotoxic effect (cardiac conduction disorders, arrhythmias, ischemic disorders), decreased libido.

When taking selective inhibitors of neuronal serotonin uptake, the following reactions are possible: gastroenterological - dyspeptic syndrome: abdominal pain, dyspepsia, constipation, vomiting and nausea. Increased anxiety levels, insomnia, dizziness, increased fatigue, tremors, impaired libido, loss of motivation and emotional dullness.

Selective norepinephrine reuptake inhibitors cause such side effects as: insomnia, dry mouth, dizziness, constipation, bladder atony, irritability and aggressiveness.

Tranquilizers and antidepressants: what's the difference?

Tranquilizers (anxiolytics) - substances that eliminate anxiety, fear and internal emotional tension. The mechanism of action is associated with an increase and increase in GABAergic inhibition. GABA is a biogenic substance that plays an inhibitory role in the brain.

They are prescribed as a therapy for distinct anxiety attacks, insomnia, epilepsy, as well as neurotic and neurosis-like conditions.

From this we can conclude that tranquilizers and antidepressants have different mechanisms of action and differ significantly from each other. Tranquilizers are not able to treat depressive disorders, so their appointment and use is irrational.

The power of "magic pills"

Depending on the severity of the disease and the effect of the application, several groups of drugs can be distinguished.

Strong antidepressants - are effectively used in the treatment of severe depression:

1. Imipramine - has a pronounced antidepressant and sedative properties. The onset of the therapeutic effect is observed after 2-3 weeks. Side effects: tachycardia, constipation, urination disorders and dry mouth.
2. Maprotiline, Amitriptyline - similar to Imipramine.
3. Paroxetine - high antidepressant activity and anxiolytic action. It is taken once a day. The therapeutic effect develops within 1-4 weeks after the start of treatment.

Light antidepressants - are prescribed in cases of moderate and mild depression:

1. Doxepin - improves mood, eliminates apathy and depression. A positive effect of therapy is observed after 2-3 weeks of taking the drug.
2. Mianserin - has antidepressant, sedative and hypnotic properties.
3. Tianeptine - relieves motor retardation, improves mood, increases the overall tone of the body. It leads to the disappearance of somatic complaints caused by anxiety. Due to the presence of a balanced action, it is indicated for anxious and inhibited depressions.

Herbal natural antidepressants:

1. St. John's wort - contains hepericin, which has antidepressant properties.
2. Novo-Passit - it includes valerian, hops, St. John's wort, hawthorn, lemon balm. Promotes the disappearance of anxiety, tension and headaches.
3. Persen - also incorporates a collection of herbs of peppermint, lemon balm, valerian. Has a sedative effect.

Hawthorn, wild rose - have a sedative property.

Our TOP 30: the best antidepressants

We analyzed almost all antidepressants that are available for sale at the end of 2016, studied the reviews and compiled a list of the top 30 drugs that have virtually no side effects, but at the same time are very effective and perform their tasks well (each one):

1. Agomelatine is used for episodes of major depression of various origins. The effect comes after 2 weeks.
2. Adepress - provokes inhibition of serotonin uptake, is used for depressive episodes, the effect occurs after 7-14 days.
3. Azafen - used for depressive episodes. The treatment course is at least 1.5 months.
4. Azona - increases the content of serotonin, is included in the group of strong antidepressants.
5. Aleval - prevention and treatment of depressive conditions of various etiologies.
6. Amizol - prescribed for anxiety and arousal, behavioral disorders, depressive episodes.
7. Anafranil - stimulation of catecholaminergic transmission. It has an adrenoblocking and anticholinergic effect. Scope of application - depressive episodes, obsessive-compulsive disorders and neuroses.
8. Asentra is a specific serotonin reuptake inhibitor. Indicated in panic disorders, in the treatment of depression.
9. Aurorix is ​​an MAO-A inhibitor. Used for depression and phobias.
10. Brintellix is ​​an antagonist of serotonin receptors 3, 7, 1d, an agonist of 1a serotonin receptors, correction of anxiety disorders and depressive states.
11. Valdoxan is a stimulant of melatonin receptors, to a small extent a blocker of a subgroup of serotonin receptors. Therapy for anxiety and depression.
12. Velaksin - an antidepressant of another chemical group, enhances neurotransmitter activity.
13. Wellbutrin - used for mild depression.
14. Venlaxor is a powerful serotonin reuptake inhibitor. Weak β-blocker. Therapy for depression and anxiety disorders.
15. Heptor - in addition to antidepressant activity, has an antioxidant and hepatoprotective effect. Well tolerated.
16. Herbion Hypericum is a herbal preparation that belongs to the group of natural antidepressants. It is prescribed for mild depression and panic attacks.
17. Deprex - an antidepressant has an antihistamine effect, is used in the treatment of mixed anxiety and depressive disorders.
18. Deprefolt is a serotonin reuptake inhibitor that has little effect on dopamine and norepinephrine. There is no stimulating and sedative effect. The effect develops 2 weeks after administration.
19. Deprim - antidepressant and sedative effect occurs due to the presence of St. John's wort extract. Approved for the treatment of children.
20. Doxepin is a serotonin H1 receptor blocker. The action develops through the days after the start of the reception. Indications - anxiety, depression, panic conditions.
21. Zoloft - the scope is not limited to depressive episodes. It is prescribed for social phobias, panic disorders.
22. Ixel is a broad-spectrum antidepressant, a selective serotonin reuptake blocker.
23. Coaxil - increases the synaptic uptake of serotonin. The effect occurs within 21 days.
24. Maprotiline - is used for endogenous, psychogenic, somatogenic depression. The mechanism of action is based on the inhibition of serotonin uptake.
25. Miansan is a stimulant of adrenergic transmission in the brain. It is prescribed for hypochondria and depression of various origins.
26. Miracitol - enhances the action of serotonin, increases its content in the synapse. In combination with monoamine oxidase inhibitors, it has pronounced adverse reactions.
27. Negrustin is an antidepressant of plant origin. Effective in mild depressive disorders.
28. Neuvelong is a serotonin and norepinephrine reuptake inhibitor.
29. Prodep - selectively blocks the uptake of serotonin, increasing its concentration. Does not cause a decrease in the activity of β-adrenergic receptors. Effective in depression.
30. Citalon is a high-precision serotonin uptake blocker that minimally affects the concentration of dopamine and norepinephrine.

There is something for everyone

Antidepressants are most often expensive, we have compiled a list of the most inexpensive of them by increasing price, at the beginning of which are the cheapest drugs, and at the end of the more expensive ones:

• The most famous antidepressant is the most and cheapest (maybe that's why it's so popular) Fluoxetine 10 mg 20 capsules - 35 rubles;
• Amitriptyline 25 mg 50 tabs - 51 rubles;
• Pyrazidol 25 mg 50 tabs - 160 rubles;
• Azafen 25 mg 50 tabs - 204 rubles;
• Deprim 60 mg 30 tabs - 219 rubles;
• Paroxetine 20 mg 30 tabs - 358 rubles;
• Melipramine 25 mg 50 tabs - 361 rubles;
• Adepress 20 mg 30 tabs - 551 rubles;
• Velaksin 37.5 mg 28 tabs - 680 rubles;
• Paxil 20 mg 30 tabs - 725 rubles;
• Reksetin 20 mg 30 tabs - 781 rubles;
• Velaksin 75 mg 28 tabs - 880 rubles;
• Stimuloton 50 mg 30 tabrubs;
• Cipramil 20 mg 15 tabs - 899 rubles;
• Venlaxor 75 mg 30 tabrubs

The truth is always beyond theory

To understand the whole point about modern, even the best antidepressants, to understand what their benefits and harms are, it is also necessary to study the reviews of people who had to take them. As you can see, there is nothing good in their reception.

Tried to fight depression with antidepressants. She quit, because the result is depressing. I looked for a lot of information about them, read a lot of sites. There is conflicting information everywhere, but wherever I read it, they write that there is nothing good in them. She herself experienced shaking, breaking, dilated pupils. Frightened, I decided that they do not need me.

My wife took Paxil for a year after giving birth. She said that her health remains just as bad. I quit, but the withdrawal syndrome began - tears were shed, there was withdrawal, my hand reached for the pills. After that, he speaks negatively about antidepressants. I haven't tried.

And antidepressants helped me, the drug Neurofulol helped, it is sold without a prescription. Good for depressive episodes. Adjusts the central nervous system for well-functioning work. I felt great about it. Now I don’t need such drugs, but I recommend it if you need to buy something without prescriptions. If a stronger one is needed, then see a doctor.

Valerchik, Neurodok site visitor

Three years ago, depression began, while running to the clinics to the doctors, it got worse. There was no appetite, she lost interest in life, there was no sleep, her memory deteriorated. I visited a psychiatrist, he prescribed Stimulaton for me. I felt the effect at the 3rd month of taking it, I stopped thinking about the disease. I drank for about 10 months. Helped me.

It is important to remember that antidepressants are not harmless drugs and you should consult your doctor before using them. He will be able to choose the right drug and its dosage.

You should carefully monitor your mental health and contact specialized institutions in a timely manner so as not to aggravate the situation, but to get rid of the disease in time.

List of antidepressants, which drugs can be bought without a prescription?

Antidepressants are quite popular drugs. Since stress and difficulties at work, in personal life lead people to a depressive and even psychopathological state. Someone begins to drink alcohol, others go to the pharmacy or doctor for a sedative.

It should be said right away that antidepressants are very potent, so they are sold by prescription. In any case, it is necessary to consult a doctor, as drugs can cause irreversible harm to the body. Mostly herbal preparations are sold without a prescription, so if you want to relieve stress, then you can use this safe option.

Treatment of psychopathological syndromes

Psychopathological syndromes include:

• Affect syndromes;
• Delusional and hallucinatory;
• Syndromes of disturbed consciousness;
• Amnestic.

Apathy, asthenia and depression also belong to these syndromes, therefore, when they develop, they are treated with antidepressant drugs. Patients may experience anxiety, sleep disturbance, be hyperexcitable or, conversely, inhibited, so most often the doctor prescribes a whole range of drugs that help normalize this condition.

We previously reviewed drugs for the treatment of asthenia in a similar article.

More severe disorders are treated in a hospital, while mild cases such as depression can be treated on an outpatient basis.

Next generation antidepressants

Antidepressants, selective serotonin and noradrenaline reuptake blockers, are considered a new generation of drugs.

These include tools such as:

• Sertraline - treats depression, anxiety and Venlafaxine - helps with schizophrenia;
• Paroxetine - helps with anxiety, melancholy, suicidal tendencies and Opipramol - helps with somatic and alcoholic depression;
• Fluoxetine, better known as Prozac, is a weaker medicine among all of the above, but you should not abuse it, with an overdose it can go crazy.

In addition, antidepressants are divided into three types:

• balanced: Coaxil, Maprotiline, Pyrazidol and others;
• sedatives: Doxepin, Amiltriptyline, Azafen and others;
• stimulants: Fluoxetine, Imipramine, Metralindol and others.

These medicines are prescribed only by a doctor and are sold in a pharmacy strictly by prescription.

List of tricyclic drugs

Tricyclic antidepressants get their name from the structure. They are based on a triple carbon ring. They promote an increase in serotonin and norepinephrine and promote the transfer of hormones. Now scientists have found out that taking such drugs for all forms of depression is not worth it, they are used only in the most neglected situations.

• Amitriptyline and Nortripteline;
• Azaphen and Anafranil;
• Melipramin and Saroten Retard and others.

These drugs can cause various side effects, such as:

• constipation and drowsiness;
• tachycardia and muscle pain;
• nausea and loss of appetite;
• decreased potency and heart problems;
• weight gain;
• dizziness;
• dry mouth.

The safest

The safest are herbal preparations, as well as tinctures and stimulants. They are sold in pharmacies without a prescription, but they also have various contraindications, so read the annotation carefully before taking.

Some people complain about stressful situations at work, sleep problems, irritability. They try to drown out these problems by various means, considering them safe. For example, they use herbal preparations based on St. John's wort.

But such components also tend to accumulate in the body, in addition, St. John's wort causes an attack of biliary colic. Therefore, you should not constantly and uncontrollably take even the safest of the means.

It is best to trust products that also contain essential antidepressants.

Without doctor's prescriptions

Without a doctor's prescription, a pharmacy will sell:

As well as various stimulant tinctures, such as:

For kids, the “Calm” composition is often taken; Glycine is popular for stress relief. It is not worth constantly drinking these pills, it is better to move more, play sports, go to the solarium.

Consider a few popular drugs

The drug Persen

• bad sleep;
• irritability;
• strong nervous excitability.

Antidepressant Prozac

• removes emotional dependence;
• anorexia nervosa;
• eliminate premenstrual irritability;
• reduces anxiety, panic.

The drug Novo-Passit

• neurasthenia;
• burnout syndrome;
• migraine;
• eczema on the background of mental disorders.

The effect of the drug is sedative:

• relieves nervous excitability in women during menstruation and menopause;
• eliminates anxiety.

Contraindications for use:

• Individual intolerance to the components of the drug;
• Pregnancy; the period of breastfeeding;
• Children's age up to 18 years.

Herbal antidepressants without a doctor's prescription

For those who are tired at work, who have no strength, such herbal stimulants will help:

• Leuzea extract - relieves depression, improves immunity;
• Rhodiola rosea, maral root, lemongrass - immunostimulants, increase efficiency, mood. These funds have practically no side effects, except for individual intolerance. May raise blood pressure;
• Ginseng tincture. Increases resistance to stress, raises immunity, can increase sensitivity to the sun;
• Lure - helps to improve mood and promotes normal sleep.
• Hawthorn, oregano, clover, motherwort - they all have a calming effect;
• Hops, valerian and mint have antidepressant properties. Have no side effects;
• Calendula helps with overwork.

Antidepressants: list, names

These drugs have a selective effect on depression, they can be used in combination with antipsychotics to relieve affective-delusional syndromes.

Moclobemide (Aurorix) is a selective MAO inhibitor type A. It is characterized by a distinct stimulating effect in inhibited depression. Indicated in somatized depression. Omg doses per day are recommended, two to three weeks are required for the development of a thymoanaleptic effect. Contraindicated in anxiety depression.

Befol is an original domestic antidepressant with an activating effect (asthenic, anergic depressions). It is used in the depressive phase of cyclothymia. Average therapeutic doses mg / day.

Toloxatone (humoril) is close in action to moclobemide, devoid of anticholinergic and cardiotoxic properties. Effective in depression with severe lethargy in doses mg / day.

Pyrazidol (pirlindol) is an effective domestic antidepressant, a reversible inhibitor of MAO type A. It is used to treat both inhibited melancholy depressions and depressions with anxiety manifestations. It has no contraindications in the presence of glaucoma and prostatitis. The dosage of the drug is mg / day. Cholinolytic effects are not manifested, which allows the drug to be prescribed for cardiovascular pathology.

Imipramine (melipramine) is the first studied tricyclic antidepressant. It is used to treat "major depressions with a predominance of sadness, lethargy, the presence of suicidal thoughts. With oral administration of a dose of otdomg / day, parenteral administration (into the muscle, into the vein) is possible, one ampoule contains 25 mg of melipramine, the daily dose for intramuscular administration is mg.

Amitriptyline is also a "classic" tricyclic antidepressant, differs from imipramine in its powerful sedative effect, therefore it is indicated in the treatment of anxious, agitated depressions with manifestations of "vitality". In tablets, up to 350 mg / day is prescribed, parenterally up to 150 mg with intramuscular injection and up to 100 mg with intravenous administration.

Anafranil is a powerful antidepressant obtained as a result of targeted synthesis and the introduction of a chlorine atom into the imipramine molecule. It is used for the treatment of resistant depressions (psychotic variants) in dosages of domg / day for oral administration, mg / day for intravenous administration in cases of severe depression to relieve affective phases in MDP.

Pertofran - demethylated imipramine, has a more powerful activating effect compared to it, is used in the treatment of depression with depersonalization. Dosage - up to 300 mg / day (in tablets).

Trimipramine (Gerfonal) is the most powerful anti-anxiety antidepressant. The profile of psychotropic activity is close to amitriptyline. Average daily doses range from 150 to 300 mg. The drug, like amitriptyline, causes anticholinergic effects (dry mouth, urination disorders, orthostatic hypotension), which must be taken into account during the course of treatment.

Azafen (pipofezin) is a domestic antidepressant, which is indicated for the treatment of "small" depressions of the cyclothymic register. It combines moderate thymoanaleptic and sedative effects. The maximum dosage mg / day for oral use.

Maprotiline (Ludiomil) is an antidepressant of a tetracyclic structure, has a powerful thymoanaleptic effect with an anxiolytic and sedative component. Indicated in typical circular depression with ideas of self-blame, used successfully in involutional melancholy. Dosage - domg / day for oral use. Intravenously, the drug is administered intravenously for resistant depression, domg / day (60 drops per minute per 300 ml of isotonic solution). Usually doinfusions.

Mianserin (lerivon) has a mild sedative effect in small doses, which allows it to be used in the treatment of cyclothymia with insomnia. When prescribing the drug in dosages of mg / day, the phenomena of a major depressive episode are stopped orally.

Fluoxetine (Prozac) has a distinct thymoanaleptic effect with a predominantly stimulating component, it is especially effective in the presence of obsessive-phobic symptoms in the structure of depression. It belongs to the group of selective serotonin reuptake inhibitors (SSRIs), completely devoid of the antihistamine, anticholinergic and adrenolytic effects of classic tricyclic antidepressants. It has a very long half-life (60 hours). It is convenient for treatment by the fact that it is prescribed once a day for 20 mg along with the intake of food. The permissible dose is 80 mg / day. The course of treatment is at least 1-2 months.

Fevarin has a moderately pronounced thymoanaleptic effect, but at the same time, a vegetostabilizing effect is manifested. Applied doses - from 100 to 200 mg / day, is prescribed once a day in the evening.

Citalopram (Cipramil) has moderate thymoanaleptic properties with a stimulating component, belongs to the group of SSRIs and is prescribed once a day in doses when administered orally.

Sertraline (Zoloft) does not have anticholinergic and cardiotoxic properties, it gives a distinct thymoanaleptic effect with: a weak stimulating effect. It is especially effective in somatized, atypical depressions with bulimia. Assign dozemg once a day, the effect is observed in days after the start of therapy.

Paroxetine (Rexetine, Paxil) is a piperidine derivative with a complex bicyclic structure. The main properties of the psychotropic activity of paroxetine are thymoanaleptic and anxiolytic effects in the presence of manifestations of stimulation. It is effective both in classical endogenous and neurotic depressions. It has a positive effect both in dreary and inhibited variants, while it is not inferior in activity to imipramine. Found: preventive effect of paxil in unipolar depressive phases. It is prescribed once a day in dozemg / day.

Cymbalta (duloxetine) is used to treat depression with the presence of panic attacks, it is prescribed in pomg capsules once a day.

Side effects

Side effects of these drugs are manifested by hypotension, sinus tachycardia, arrhythmia, impaired intracardiac conduction, a number of signs of bone marrow depression (agranulocytosis, thrombocytopenia, hemolytic anemia, etc.). Other vegetative symptoms include dry mucous membranes, accommodation disorders, intestinal hypotension, and urinary retention. This is most often noted with the use of tricyclic antidepressants. The use of tricyclic drugs is also accompanied by an increase in appetite, an increase in body weight. Seroton reuptake inhibitor drugs are safer, but can also cause headaches, insomnia, anxiety, and depotent effects. When these drugs are combined with tricyclic drugs, serotonin syndrome phenomena can be observed with an increase in body temperature, signs of intoxication, and disorders in the cardiovascular sphere.

Tags: list of antidepressants, names of antidepressants

Top list of the best over-the-counter antidepressants

Depression is not uncommon for a modern person. But with such a diagnosis, few people are in a hurry to turn to a psychotherapist, preferring to take over-the-counter antidepressants.

Can depression be cured with over-the-counter antidepressants, and how to choose the most effective drug?

In the pharmacy you can find antidepressants without prescriptions that will help relieve anxiety, depression, and normalize sleep.

When you need antidepressants without a prescription

Before choosing an antidepressant, you need to make sure whether you really need to fight your condition with medication or whether it is enough to eliminate the factors that cause depression. Before using antidepressants, experts recommend minimizing stress, reviewing lifestyle, normalizing rest and work.

It should be noted right away that for people with severe depressive disorders, antidepressants sold in pharmacies without a prescription are not suitable. Drugs against depression have a lot of side effects, and their intake and dosage should be selected by the doctor on a strictly individual basis.

Antidepressants have a different composition and chemical structure, and the way they act on the body is very different. After all, depression depression is different - and the same drug in the same dosage in some patients can lead to recovery, while others, on the contrary, lead to a worsening of the condition. Therefore, using antidepressants without a prescription is very imprudent if the depressive state already has the character of a mental illness, and not a temporary nervous breakdown.

Note! Without a prescription, sedatives, amino acids, metabolic drugs, "weak" tranquilizers and nootropics are usually dispensed. It is impossible to buy strong antidepressants without prescriptions in a pharmacy.

If a person just needs to reduce the reaction of the nervous system to nerve stimuli, improve mood, then “light” antidepressants will undoubtedly help improve the quality of life. In addition, these drugs help with the following conditions:

• With pain that is indefinite;
• With violations of appetite and sleep;
• With frequent bouts of unreasonable anxiety;
• With chronic fatigue;
• In the treatment of alcohol and drug addiction;
• With attention disorders;
• In the treatment of anorexia and bulimia.

Antidepressants without a prescription have a very limited list, but they all do not have side effects on the body and it is almost impossible to get poisoned by them.

The antidepressant effect of drugs is due to the stimulating effect on the human psyche. Therapeutic activity depends on the mechanism of action of the drug and the severity of the pathology.

Herbal antidepressants

It is better to start treating mild nervous disorders with herbal preparations - such antidepressants can be easily purchased without a prescription at any pharmacy. Herbal antidepressants also help with anxiety and depressive conditions that appear with stress and anxiety.

List of Russian phytopreparations for the treatment of depression

The best strong antidepressants of the new generation, a list of drugs without prescriptions

Stress and depression have so “captured” modern humanity that many people use antidepressants as food or dessert. However, few people know what are the best and most powerful antidepressants available today without a prescription from a psychotherapist, what effect they have on the psyche and brain biochemistry, and also what side effects different antidepressants have.

Safe strong antidepressants - names

Any strong antidepressants, including the so-called "safe" ones, are drugs (essentially psychotropics) that mainly affect the level of serotonin, dopamine and norepinephrine (neurotransmitters) in the biochemistry of the brain in depressive and stress disorders.

It is with a decrease in the listed “hormones of joy”, often with stress, emotional and mental overstrain, psychotrauma, etc. a person may experience depression. Strong safe antidepressants help improve mood, remove sadness, anxiety, restlessness and irritability, they improve sleep phases and make a person more efficient.

Antidepressants have different names, more often these are trademarks, behind which the common international name of an antidepressant drug may be hidden.

The best antidepressants - a list of new generation drugs

Many of the best new generation antidepressants are available over-the-counter and are mostly made up of various herbs and other natural substances. However, this does not mean at all that they are completely safe and can really save a person from depression once and for all.

Antidepressants - a list of new generation drugs:

Natural, herbal antidepressants

The main natural antidepressants on herbs:

Tricyclic antidepressants

Tricyclic antidepressants - list of drugs:

What is better than taking antidepressants? Psychotherapy and psychotraining

Even the best and safest antidepressants have side effects in one way or another, besides, they do not cure the disease itself, do not remove the source of depression or stress, but only relieve symptoms, improving the emotional and mental state of a person for a while.

After stopping antidepressants, a “withdrawal syndrome” may occur and depression may soon return in an even more severe form.

Antidepressants should be taken only in crisis situations, and when the condition improves, resort to non-drug psychotherapy and psychological training. Only in this case it is possible to get rid of the very source of depression and carry out antidepressant prophylaxis for the future.

Be sure to check out the psychotherapist's journal for helpful articles and recommendations. Discuss your psychological problems in a psychological club

Antidepressants without a doctor's prescription: names, prices, list

Recently, the number of people suffering from depression has increased significantly. This is largely facilitated by the frantic rhythm of modern life, the increased level of stress. Added to this are also economic and social problems. All this cannot affect the mental and mental health of people.

People feel changes in the psyche when they are reflected in their performance and social relationships. They turn to a doctor for advice, and often he diagnoses them with depression.

What is depression and why is it dangerous?

First of all, it should be noted that one should not be afraid of this diagnosis. The disease does not indicate that the person suffering from it is mentally or mentally handicapped. It does not affect the cognitive functions of the brain, and in most cases it can be cured.

However, depression is not just a bad mood or sadness that can roll over healthy people from time to time. With depression, a person loses all interest in life, feels overwhelmed and tired all the time, and cannot make a single decision.

Depression is dangerous because it can affect the entire body, causing irreversible changes in its individual organs. In addition, with depression, relationships with others deteriorate, work becomes impossible, thoughts of suicide appear, which can sometimes be carried out.

Depression is not actually the result of a person's weak will, his insufficient efforts to correct the situation. In most cases, it is a biochemical disease caused by a metabolic disorder and a decrease in the amount of certain hormones in the brain, primarily serotonin, norepinephrine and endorphin, which act as neurotransmitters.

Therefore, as a rule, depression is not always possible to cure non-drug means. It is well known that a change of scenery, relaxation techniques and auto-training, etc., can help a person with a depressed mood. but all these methods require considerable effort on the part of the patient, his will, desire and energy. And with depression, they just don’t exist. It turns out a vicious circle. And it is often impossible to break it without the help of drugs that change the biochemical processes in the brain.

Classification of antidepressants according to the principle of action on the body

There are several options for classifying antidepressants. One of them is based on what kind of clinical effect drugs have on the nervous system. In total, three types of such actions are distinguished:

• Sedative
• Balanced
• Activating

Sedative antidepressants have a calming effect on the psyche, relieving anxiety and at the same time increasing the activity of nervous processes. Activating drugs fight well with such manifestations of depression as apathy and lethargy. Balanced drugs have a universal effect. As a rule, the sedative or stimulating effect of drugs begins to be felt from the very beginning of the intake.

Classification of antidepressants according to the principle of biochemical action

This classification is considered traditional. It is based on what chemicals are included in the drug and how they affect the biochemical processes in the nervous system.

Tricyclic antidepressants (TCAs)

A large and diverse group of drugs. TCAs have long been used in the treatment of depression and have a solid evidence base. The effectiveness of some drugs of the group allows us to consider them a benchmark for antidepressants.

Tricyclic drugs are able to increase the activity of neurotransmitters - norepinephrine and serotonin, thereby reducing the causes of depression. The name of the group was given by biochemists. It is associated with the appearance of the molecules of substances of this group, consisting of three carbon rings connected together.

TCAs are effective drugs, but have many side effects. They are observed in approximately 30% of patients.

The main drugs of the group include:

• Amitriptyline
• Imipramine
• Maprotiline
• Clomipramine
• Mianserin

Amitriptyline

Tricyclic antidepressant. It has both antidepressant and mild analgesic effects

Composition: 10 or 25 mg amitriptyline hydrochloride

Dosage form: dragee or tablets

Indications: depression, sleep disorders, behavioral disorders, mixed emotional disorders, chronic pain syndrome, migraine, enuresis.

Side effects: agitation, hallucinations, visual disturbances, tachycardia, pressure fluctuations, tachycardia, indigestion

Contraindications: heart attack, individual intolerance, lactation, intoxication with alcohol and psychotropic drugs, conduction disorders of the heart muscle.

Application: immediately after meals. The initial dose is mg at night. Gradually, the daily dose increases to 200 mg in three divided doses.

Monoamine oxidase inhibitors (MAO inhibitors)

These are first generation antidepressants.

Monoamine oxidase is an enzyme that destroys various hormones, including neurotransmitters. MAO inhibitors interfere with this process, due to which the number of neurotransmitters in the nervous system increases, which in turn leads to the activation of mental processes.

MAO inhibitors are quite effective and cheap antidepressants, but they have a large number of side effects. These include:

• hypotension
• hallucinations
• Insomnia
• Agitation
• constipation
• Headache
• Dizziness
• sexual dysfunction
• visual impairment

When taking certain drugs, you should also follow a special diet to avoid the ingestion of potentially dangerous enzymes that are metabolized with the help of MAO.

The most modern antidepressants of this class have the ability to inhibit only one of two types of the enzyme - MAO-A or MAO-B. These antidepressants have fewer side effects and are called selective inhibitors. Non-selective inhibitors are currently rarely used. Their main advantage is their low price.

The main selective MAO inhibitors:

• Moclobemide
• Pirlindol (pyrazidol)
• befol
• Metralindol
• Garmalin
• Selegiline
• Rasagiline

Moclobemide

Antidepressant, selective MAO inhibitor. It acts mainly on MAO type A, has an antidepressant and immunostimulating effect.

Indications: schizophrenia, social phobia, manic-depressive psychosis, alcoholism, reactive, senile, neurotic depression

Contraindications: exacerbation of mental illness, agitation, confusion, agitation, pregnancy and lactation.

Side effects: headaches, dizziness, upset stomach and intestines

Application: after meals. The daily dosage is mg, three doses per day. The dosage is gradually increased.

Selective serotonin reuptake inhibitors (SSRIs)

These drugs belong to the third generation of antidepressants. They are relatively easily tolerated by patients and have fewer contraindications and side effects compared to TCAs and MAO inhibitors. Their overdose is not so dangerous as compared to other groups of drugs. The main indication for drug treatment is major depressive disorder.

Photo: Sherry Yates Young/Shutterstock.com

The principle of operation of the drugs is based on the fact that the neurotransmitter serotonin, which is used to transmit impulses between neuron contacts, when exposed to SSRIs, does not return back to the cell that transmits the nerve impulse, but is transferred to another cell. Thus, antidepressants such as SSRIs increase the activity of serotonin in the neural circuit, which has a beneficial effect on brain cells affected by depression.

As a rule, drugs of this group are especially effective in severe depression. In depressive disorders of minor and moderate severity, the effect of drugs is not so noticeable. However, a number of doctors have a different opinion, which is that in severe forms of depression, it is preferable to use proven TCAs.

The therapeutic effect of SSRIs does not appear immediately, usually after 2-5 weeks of use.

The class includes substances such as:

• fluoxetine
• Paroxetine
• Citalopram
• Sertraline
• fluvoxamine
• Escitalopram

fluoxetine

Antidepressant, selective serotonin reuptake inhibitor. Has an antidepressant effect, relieves feelings of depression

Release form: 10 mg tablets

Indications: depression of various origins, obsessive-compulsive disorder, bulimia nervosa

Contraindications: epilepsy, convulsive tendencies, severe renal or hepatic insufficiency, glaucoma, adenoma, suicidal tendencies, taking MAO inhibitors

Side effects: hyperhidrosis, chills, serotonin intoxication, indigestion

Application: regardless of the meal. The usual scheme is once a day, in the morning, 20 mg. After three weeks, the dose can be doubled.

Fluoxetine analogues: Deprex, Prodep, Prozac

Other types of drugs

There are also other groups of drugs, for example, norepinephrine reuptake inhibitors, selective norepinephrine reuptake inhibitors, noradrenergic and specific serotonergic drugs, melatonergic antidepressants. Among these drugs are Bupropion (Zyban), Maprotiline, Reboxetine, Mirtazapine, Trazadone, Agomelatine. All of these are good antidepressants, proven in practice.

Bupropion (Zyban)

Antidepressant, selective norepinephrine and dopamine reuptake inhibitor. Antagonist of nicotinic receptors, due to which it is widely used in the treatment of nicotine addiction.

Release form: Tablets 150 and 300 mg.

Indications: depression, social phobia, nicotine addiction, seasonal affective disorders.

Contraindications: allergy to components, age up to 18 years, simultaneous use with MAO inhibitors, anorexia nervosa, convulsive disorders.

Side effects: an overdose of the drug is extremely dangerous, which can cause epileptic seizures (2% of patients at a dose of 600 mg). Urticaria, anorexia or lack of appetite, tremor, tachycardia are also observed.

Application: the medicine should be taken once a day, in the morning. The typical dose is 150 mg, with a maximum daily dose of 300 mg.

Next generation antidepressants

These are new drugs, which mainly include antidepressants of the SSRI class. Among drugs synthesized relatively recently, drugs have shown themselves well:

• Sertraline
• fluoxetine
• fluvoxamine
• Mirtazalin
• Escitalopram

The difference between antidepressants and tranquilizers

Many believe that tranquilizers are a good remedy for depression. But in fact, this is not the case, although tranquilizers are often used to treat depression.

What is the difference between these drug classes? Antidepressants are drugs that generally have a stimulating effect, improve mood and relieve mental problems associated with a lack of certain neurotransmitters. This class of drugs works for a long time and does not affect people with a healthy nervous system.

Tranquilizers, as a rule, are fast-acting drugs. They can be used to fight depression, but mostly as ancillary drugs. The essence of their impact on the human psyche is not in the correction of his emotional background in the long term, as in drugs for depression, but in the suppression of manifestations of negative emotions. They can be used as a means to reduce fear, anxiety, agitation, panic attacks, etc. Thus, they are more of an anti-anxiety and sedative than an antidepressant. In addition, during the course of treatment, most tranquilizers, especially diazepine drugs, are addictive and addictive.

Can you buy antidepressants without a prescription?

According to the current rules for dispensing medicines in Russia, in order to obtain psychotropic drugs in pharmacies, a doctor's prescription is required, that is, a prescription. And antidepressants are no exception. Therefore, theoretically strong antidepressants cannot be bought without prescriptions. In practice, of course, pharmacists can sometimes turn a blind eye to the rules in pursuit of profit, but this phenomenon cannot be taken for granted. And if you are given a medicine without a prescription in one pharmacy, this does not mean that the situation will be the same in another.

You can buy without a doctor's prescription only drugs for the treatment of mild depressive disorders such as Afobazol, "daytime" tranquilizers and herbal preparations. But in most cases, it is difficult to attribute them to real antidepressants. It would be more correct to classify them as sedative drugs.

Afobazole

Russian-made anti-anxiety, anxiolytic and mild antidepressant without side effects. OTC drug.

Release form: Tablets 5 and 10 mg

Indications: anxiety disorders and conditions of various origins, sleep disorders, neurocirculatory dystonia, alcohol withdrawal.

Side effects: Side effects while taking the drug are extremely rare. These can be allergic reactions, disorders of the gastrointestinal tract, headaches.

Application: It is advisable to take the drug after meals. A single dose is 10 mg, daily - 30 mg. The course of treatment is 2-4 weeks.

Contraindications: hypersensitivity to the components of the tablets, age up to 18 years, pregnancy and lactation

Why is self-treatment of depression dangerous?

There are many factors to consider when treating depression. This is the state of health of the patient, the physiological parameters of his body, the type of disease, and other drugs he takes. Not every patient can independently analyze all the factors and choose the medicine and its dosage in such a way that it would be useful and would not bring harm. Only specialists - psychotherapists and neuropathologists with extensive practical experience, will be able to solve this problem and say which antidepressants are better to use for a particular patient. After all, the same medicine used by different people will lead in one case to a complete cure, in another it will not have any effect, in the third it may even aggravate the situation.

Almost all depression medications, even the mildest and safest, can cause side effects. And strong drugs without side effects simply do not exist. Especially dangerous is prolonged uncontrolled use of drugs or excess dosage. In this case, intoxication of the body with serotonin (serotonin syndrome) can occur, which can lead to death.

How to get a prescription for the drug?

If you think that you have depression, it is recommended to consult a psychotherapist or neurologist. Only he can carefully examine your symptoms and prescribe the appropriate remedy for your case.

Herbal remedies for depression

The most popular herbal preparations for raising the mood today contain extracts of mint, chamomile, valerian, motherwort. But preparations containing St. John's wort showed the greatest effectiveness in depression.

The mechanism of the therapeutic action of St. John's wort has not yet been clearly elucidated, but scientists believe that the enzyme hypericin contained in it is able to accelerate the synthesis of norepinephrine from dopamine. St. John's wort also contains other substances that have a beneficial effect on the nervous system and other body systems - flavonoids, tannins, essential oils.

Photo: Ron Rowan Photography/Shutterstock.com

Hypericum preparations are mild antidepressants. They will not help with any depression, especially with its severe forms. However, the effectiveness of St. John's wort in mild to moderate depression has been proven by serious clinical studies, in which it proved to be no worse, and in some respects even better than the popular tricyclic drugs for depression and SSRIs. In addition, St. John's wort preparations have a relatively small number of side effects. They can be taken by children from the age of 12. Among the negative effects of taking St.

Hypericum-based medicines are sold without a prescription. So if you're looking for over-the-counter depression remedies, this class of drugs may be your best bet.

Some preparations based on St. John's wort:

• Negrustin
• Deprim
• Gelarium Hypericum
• Neuroplant

Negrustin

Antidepressant and anti-anxiety agent based on St. John's wort extract

Release form: there are two forms of release - capsules containing 425 mg of St. John's wort extract and a solution for internal administration, poured into 50 and 100 ml bottles.

Indications: mild and moderate depression, hypochondriacal depression, anxiety, manic-depressive states, chronic fatigue syndrome.

Contraindications: photodermatitis, endogenous depression, pregnancy and lactation, simultaneous use of MAO inhibitors, cyclosporine, digoxin and some other drugs.

Side effects: eczema, urticaria, increased allergic reactions, gastrointestinal disorders, headaches, iron deficiency anemia.

Application: three times a day is taken in a capsule of Negrustin or 1 ml of solution. Children under 16 are prescribed 1-2 capsules per day. The maximum daily dose is 6 capsules or 6 ml of solution.

Antidepressants are medicines that are aimed at treating and eliminating various types of depression. A distinction should be made between simply bad mood and drug-induced depression. You do not need to swallow pills if you are able to survive stress on your own. Antidepressants have a number of side effects that can make the situation worse.

Depression can lead to a variety of illnesses.

There are visible and invisible causes of depression. The visible ones can be recognized immediately.

It could be:

1. Loss of loved ones;
2. Job loss;
3. Some bright unpleasant event in life.

And there are invisible reasons when neither you nor the doctor can immediately determine a sharp deterioration in the emotional state. Perhaps something was accumulating inside, or you realized some unpleasant things.

Most often, emotional disorders in people are observed in the spring and autumn periods. This is due to the fact that there is a sharp change in the weather. In one case - for the better, in the other - for the worse. Such changes are reflected in our condition, and in some people too much.

How to get rid of depression?

So that the body does not experience a deficiency of serotonin, try to always make your life brighter than it is now. Say yes to your life!

1. Participate in all the activities that someone offers you. If there are none, then most likely you have a bunch of themed evenings and parties in the city.
2. Get involved in sports, if not professionally, then at least as an amateur. At any time of the year, you can lead an interesting sports life: rollerblading or skating, cycling or skiing, swimming in the river or in the pool, exercising in the gym.
3. Find new friends. You can get acquainted both on the Internet and in everyday life. You will see how diverse life can be.
4. Eat right, sometimes allow yourself chocolate, eat fruits more often, especially bananas and citrus fruits. They will help lift your mood, and antidepressants may not even come in handy;
5. Travel when possible. If it is not there, then explore the nearby territories, there will also be a lot of interesting things there.
6. Find a circle of interests - participation in some kind of party, in various business communities, musical events can very well change your life. Try to find them, if it didn’t work out, organize it yourself!

Names of antidepressants

Now we will analyze what antidepressants are. It should be remembered, as a rule, they are prohibited for sale without a prescription. Therefore, either you go to the doctor and he writes you a prescription, or you use antidepressant drugs that you can buy at the pharmacy, more on that below. Of course, private pharmacies, for their own benefit, can sell antidepressants without a prescription, taking risks and transgressing the law. But you need to understand that such laws were invented for a reason. Taking strong antidepressants puts your health at risk.

Medications for depression:

• tryptophan;
• rexetine;
• noofen;
• fluoxetine;
• sonopax;
• amitriptyline;
• paxil;
• grandaxin.

a) Paxil b) "Noofen"

Side effects of antidepressants

Self-administration of such drugs can cause unpleasant side effects.

It could be:

• headache;
• vomit;
• diarrhea;
• insomnia;
• anxiety;
• lack of appetite;
• temperature.

And other disorders. They depend on the type of medicine.

Taking antidepressants - reviews

In their reviews, women often complain about side effects, but there are those for whom the drugs really helped.

A lot of people have already tried antidepressants, some of them were prescribed by a doctor, others managed to buy them on their own. See for yourself how to proceed, but we recommend that you first consult with a knowledgeable person. Because you can immerse yourself in the state of an even larger vegetable than you were before.

Antidepressants without a prescription

There are antidepressants that you can buy at the pharmacy without a prescription:

1. afobazole;
2. new pass;
3. hawthorn tincture;
4. Valerian tincture;
5. negrustin.

Most of them are made on the basis of herbs and do not cause addiction, do not harm the body. If the situation has not gone far, then it is better to do with simple drugs.

Treatment with antidepressants - consequences

Antidepressants can cause addiction, hallucinations, sleep disturbance. Possible decreased libido. Therefore, strong drugs should be taken only as directed by a doctor. In mild cases, you can get by with a tincture of hawthorn or valerian.